Pentobarbital will lessen the level or influence of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar. pentobarbital will decrease the level or effect of ramelteon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown. pentobarbital and daridorexant each enhance sedation. Modify Therapy/Watch Intently.... https://sodium-pentobarbital-what63840.csublogs.com/27604282/the-2-minute-rule-for-sodium-pentobarbital-euthanasia-dose