Close to eighty% of TTP is triggered by deficient activity of ADAMTS13. ADAMTS13 deficiency may be constitutive, due to biallelic ADAMTS13 pathogenic variants; or obtained, due to an inhibitory antibody. Analysis of ADAMTS13 action is done applying tests according to the potential on the protease to cleave typical VWF multimers https://chillerhire71481.designertoblog.com/65723452/air-handling-units-ahus-no-further-a-mystery