Substitution at R3 using a halogen or alkoxy group (74f–74i) led to a slight rise in cellular potency Using the halide analogs (74g–h) showing best the potency from the group. More optimization resulted in the discovery of 74i–j, with 74k as one of the most active compound during the series https://indazoleproducts87541.pages10.com/indazole-3-carboxamide-an-overview-66962421